Alfried Krupp Krankenhaus, ALS outpatient clinic
Foundation year2016
DirectorProf. Dr. med. Peter Berlit
Principal investigatorDr. med. Torsten Grehl
Our outpatient clinic at Alfried Krupp Krankenhaus, Essen, provides diagnosis and multidisciplinary care to around 500 patients with ALS and related motoneuron diseases. Our clinical research currently focuses on managed care, shared decison making (SDM) and palliative care. The ALS outpatient clinic cooperates with the ALS management platform AmbulanzPartner (www.ambulanzpartner.de).
Contact Information
AddressEssenAlfried-Krupp-Straße 2145131 Germany
ContactDr. med. Torsten Grehl
Phone004902014342913
Emailtorsten.grehl@rub.de
Restricted information
Serving population
1.000.0000 or more
Patient resources
Population based register
Clinic based register
Geographically matched controls
Number of muscle samples
0
Number of skin samples
80
Number of spinal cord samples
0
Number of brain samples
0
Number of IPS cell samples
5
Banks
TypeALS PatientsControlsOther
DNA Bank
370
100
0
Serum Bank
370
100
50
Research activities
Clinical management research
Neuro epidemiology
Neuro physiology
Neuro imaging
Neuro psychology
Neuro pathology
Genomics
Transcriptomics
Metabolomics
Publication
- Dorst, J., et al. (2015). “Percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis: a prospective observational study.” J Neurol 262(4): 849-858.
- Gerardo-Nava, J., et al. (2014). “Spinal cord organotypic slice cultures for the study of regenerating motor axon interactions with 3D scaffolds.” Biomaterials 35(14): 4288-4296.
- Grehl, T. (2013). “[Diagnostics and therapy for amyotrophic lateral sclerosis].” Fortschr Neurol Psychiatr 81(10): 592-603;
- Gerardo-Nava, J., et al. (2013). “Differential pattern of neuroprotection in lumbar, cervical and thoracic spinal cord segments in an organotypic rat model of glutamate-induced excitotoxicity.” J Chem Neuroanat 53: 11-17.
- Synofzik, M., et al. (2012). “Screening in ALS and FTD patients reveals 3 novel UBQLN2 mutations outside the PXX domain and a pure FTD phenotype.” Neurobiol Aging 33(12): 2949 e2913-2947.