Tricals

    Clinical Centre for Neuromuscular Diseases-Azienda Ospedaliero-Universitaria Pisana

    Foundation year1980
    DirectorProf.Gabrielle Siciliano
    Principal investigatorProf.Gabrielle Siciliano

    Since a long time, our Centre is the referral Centre for the entire North-West Tuscany and one of the most important Centre in Tuscany.

    The Center belongs to ERN Euro-NMD, and it is considered as a national reference Centre for care of Motor Neuron Diseases.

    Contact Information

    AddressPisaVia Roma 6756100 Italy

    ContactClinical Centre for Neuromuscular Diseases-Azienda Ospedaliero-Universitaria Pisana

    Phone050993212
    Emailgabriele.siciliano@unipi.it

    Restricted information

    Serving population
    Our patients come from different places across Tuscany. We are the referring Centre for North-west Tuscany and one of the most important Centre in Tuscany and in Central Italy. Patients coming from other regions of Central and South Italy often require an evaluation in our Centre to achieve a second opinion on diagnosis.

    Patient resources

    Population based register
    Clinic based register
    Geographically matched controls

    Banks

    TypeALS PatientsControlsOther
    DNA bank
    150
    0
    0
    Serum bank
    150
    0
    0
    RNA bank
    10
    0
    0

    Research activities

    Clinical management research
    Neuro epidemiology
    Neuro physiology
    Neuro imaging
    Neuro psychology
    Neuro pathology
    Genomics
    Transcriptomics
    Metabolomics

    Publication

    1. Beghi E, Pupillo E, Bianchi E, Bonetto V, Luotti S, Pasetto L, Bendotti C, Tortarolo M, Sironi F, Camporeale L, Sherman AV, Paganoni S, Scognamiglio A, De Marchi F, Bongioanni P, Del Carratore R, Caponnetto C, Diamanti L, Martinelli D, Calvo A, Filosto M, Padovani A, Piccinelli SC, Ricci C, Dalla Giacoma S, De Angelis N, Inghilleri M, Spataro R, La Bella V, Logroscino G, Lunetta C, Tarlarini C, Mandrioli J, Martinelli I, Simonini C, Zucchi E, Monsurrò MR, Ricciardi D, Trojsi F, Riva N, Filippi M, Simone IL, Sorarù G, Spera C, Florio L, Messina S, Russo M, Siciliano G, Conte A, Saddi MV, Carboni N, Mazzini L; RNS60-ALS Study Group. Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial. Eur J Neurol. 2023 Jan;30(1):69-86.doi: 10.1111/ene.15573. Epub 2022 Oct 7.
    2. Donatelli G, Costagli M, Cecchi P, Migaleddu G, Bianchi F, Frumento P, Siciliano G, Cosottini M. Motor cortical patterns of upper motor neuron pathology in amyotrophic lateral sclerosis: A 3 T MRI study with iron-sensitive sequences. Neuroimage Clin. 2022;35:103138. doi: 10.1016/j.nicl.2022.103138. Epub 2022 Jul 29.
    3. Cosottini M, Donatelli G, Ricca I, Bianchi F, Frosini D, Montano V, Migaleddu G, Del Prete E, Tessa A, Cecchi P, D’Amelio C, Siciliano G, Mancuso M, Santorelli FM.
      Iron-sensitive MR imaging of the primary motor cortex to differentiate hereditary spastic paraplegia from other motor neuron diseases. Eur Radiol. 2022 Dec;32(12):8058-8064. doi: 10.1007/s00330-022-08865-6. Epub 2022 May 20.
    4. Costagli M, Donatelli G, Cecchi P, Bosco P, Migaleddu G, Siciliano G, Cosottini M. Distribution Indices of Magnetic Susceptibility Values in the Primary Motor Cortex Enable to Classify Patients with Amyotrophic Lateral Sclerosis.
      Brain Sci. 2022 Jul 18;12(7):942. doi: 10.3390/brainsci12070942.
    5. Diamanti L, Borrelli P, Dubbioso R, Capasso M, Morelli C, Lunetta C, Petrucci A, Mora G, Volanti P, Inghilleri M, Tremolizzo L, Mandrioli J, Mazzini L, Vedovello M, Siciliano G, Filosto M, Matà S, Montomoli C; DYALS Study Group. Validation of the DYALS (dysphagia in amyotrophic lateral sclerosis) questionnaire for the evaluation of dysphagia in ALS patients. Neurol Sci . 2022 May;43(5):3195-3200. doi: 10.1007/s10072-021-05775-1. Epub 2021 Dec 1.