The Neuromuscular Unit provides primary and secondary care for patients with motor neurone diseases and neuromuscular diseases. We cover the full range of diagnostics, provide ICU treatment, feeding tube placement and NIV services, regular clinical visits, and coordination of support measures. Clinical trials, clinical research and basic research in animal and cell models form a bench to bedside concept which is integrated into national, european and international consortia (ie. MND-NET, SOPHIA, NISALS, ERMCC-NDEG, PYRAMID, ONWebDUALS).
| Hans Berger Dept. of Neurology, University Hospital Jena | |
|---|---|
| Foundation year | 2007 |
| Director | Prof. Dr. med. Otto W. Witte |
| Principal investigator | PD Dr. med. Julian Grosskreutz |
| Contact information | |
|---|---|
| Address | Erlanger Allee 101 |
| Contact | Dr. rer. nat. Beatrice Stubendorff |
| Phone | +49 3641 9323488 |
| Fax | +49 3641 9323477 |
| als-neuro@med.uni-jena.de | |
| Website | Visit the website |
Publications
- Native chromatographic sample preparation of serum, plasma and cerebrospinal fluid does not comprise a risk for proteolytic biomarker loss. Pesek J, Krüger T, Krieg N, Schiel M, Norgauer J, Großkreutz J, Rhode H. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Feb 18;923-924C:102-109. doi: 10.1016/j.jchromb.2013.02.014. [Epub ahead of print]
- MRI in amyotrophic lateral sclerosis: more than a promise. Grosskreutz J. J Neurol Neurosurg Psychiatry. 2012 Dec 25. [Epub ahead of print]
- Diffusion tensor imaging patterns differ in bulbar and limb onset amyotrophic lateral sclerosis. Prell T, Peschel T, Hartung V, Kaufmann J, Klauschies R, Bodammer N, Kollewe K, Dengler R, Grosskreutz J. Clin Neurol Neurosurg. 2012 Dec 21. doi:pii: S0303-8467(12)00609-9. 10.1016/j.clineuro.2012.11.031.
- Longitudinal diffusion tensor imaging in amyotrophic lateral sclerosis. Keil C, Prell T, Peschel T, Hartung V, Dengler R, Grosskreutz J. BMC Neurosci. 2012 Nov 8;13:141. doi: 10.1186/1471-2202-13-141.
- Proteome analysis of body fluids for amyotrophic lateral sclerosis biomarker discovery. Krüger T, Lautenschläger J, Grosskreutz J, Rhode H. Proteomics Clin Appl. 2013 Jan;7(1-2):123-35. doi: 10.1002/prca.201200067.
Restricted information
| Serving population | |
|---|---|
| Serving population | 1.000.0000 or more |
| Patient resources | |
|---|---|
| Population based register | No |
| Clinic based register | Yes |
| Geographically matched controls | Yes |
| Number of muscle samples | 50 |
| Number of skin samples | 20 |
| Number of spinal cord samples | 10 |
| Number of brain samples | 10 |
Banks
| Type | ALS Patients | Controls | Other |
|---|---|---|---|
| DNA Bank | 300 | 150 | 200 |
| CSF Bank | 80 | 30 | 100 |
| Serum Bank | 200 | 100 | 100 |
| RNA Bank | 30 | 100 | 100 |
| Research activities | |
|---|---|
| Clinical management research | Yes |
| Neuro epidemiology | Yes |
| Neuro physiology | Yes |
| Neuro imaging | Yes |
| Neuro psychology | Yes |
| Neuro pathology | Yes |
| Genomics | Yes |
| Transcriptomics | Yes |
| Metabolomics | Yes |
Clinical Trials - Industry sponsored
| Name | Type | Patients |
|---|---|---|
| EMPOWER | EMPOWER | 23 |
| ENVISION | ENVISION | 16 |
| NoGo-A | NoGo-A | 14 |
Clinical Trials - Investigator initiated
| Name | Type | Patients |
|---|---|---|
| ALS GERP | ALS GERP | 22 |
| Rasagilin | Rasagilin | 15 |
| JERN (Jena Nutrition Assessment Trial) | JERN (Jena Nutrition Assessment Trial) | 50 |
| LIPCAL-ALS | LIPCAL-ALS | 20 |