The ALS unit at Akershus University Hospital has a catchment area of approximately 500.000 people. The research interest in ALS at the hospital is quite new and is focused on epidemiology and disease mechanisms. The epidemiological research takes advantage of high quality compulsory health registries in Norway, which allows us to track ALS mortality over several decades, and during more recent years also use of ALS-speecific prescription drugs. We have currently ongoing projects sponsored by the Health authority on molecular disease mechanisms including generation of Ips cell lines.
| Akershus University Hospital | |
|---|---|
| Foundation year | 2011 |
| Director | Professor Trygve Holmøy |
| Principal investigator | Professor Trygve Holmøy |
| Contact information | |
|---|---|
| Address | Box 1000, |
| Contact | Trygve Holmøy |
| Phone | +47 915 02900 |
| trygve.holmoy@medisisn.uio.no | |
Publications
- Nordin A, Akimoto C, Wuolikainen A, Alstermark H, Forsberg K, Baumann P, Pinto S, de Carvalho M, Hübers A, Nordin F, Ludolph AC, Weishaupt JH, Meyer T, Grehl T, Schweikert K, Weber M, Burkhardt C, Neuwirth C, Holmøy T, Morita M, Tysnes OB, Benatar M, Wuu J, Lange DJ, Bisgård C, Asgari N, Tarvainen I, Brännström T, Andersen PM. Sequence variations in C9orf72 downstream of the hexanucleotide repeat region and its effect on repeat-primed PCR interpretation: a large multinational screening study. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18(3-4):256-264.
- Nakken O, Lindstrøm JC, Tysnes OB, Holmøy T. Mortality trends of amyotrophic lateral sclerosis in Norway 1951-2014: an age-period-cohort study.J Neurol. 2016 ;263(12):2378-2385.
- Lerum SV, Solbraekke KN, Holmøy T, Frich JC. Unstable terminality: negotiating the meaning of chronicity and terminality in motor neurone disease. Sociol Health Illn. 2015;37(1):81-96.
- Holmøy T, Wilson JA, von der Lippe C, Andersen PM, Berg-Hansen P. G127R: A novel SOD1 mutation associated with rapidly evolving ALS and severe pain syndrome. Amyotroph Lateral Scler. 2010 Oct;11(5):478-80.
- Østern R, Fagerheim T, Ørstavik K, Holmøy T, Heiberg A, Lund-Petersen I, Strom TM, Nilssen Ø, Dahl A. Hereditary motor neuron disease in a large Norwegian family with a “H46R” substitution in the superoxide dismutase 1 gene. Neuromuscul Disord. 2012;22(6):511-21.
Restricted information
| Serving population | |
|---|---|
| Serving population | 500.000 |
| Patient resources | |
|---|---|
| Population based register | No |
| Clinic based register | No |
| Geographically matched controls | Yes |
| Number of IPS cell samples | 4 |
Banks
There are no banks for this centre
| Research activities | |
|---|---|
| Clinical management research | Yes |
| Neuro epidemiology | Yes |
| Neuro physiology | Yes |
| Neuro imaging | Yes |
| Neuro psychology | Yes |
| Neuro pathology | No |
| Genomics | No |
| Transcriptomics | Yes |
| Metabolomics | No |
Clinical Trials - Industry sponsored
There are no clinical trials for this centre
Clinical Trials - Investigator initiated
There are no clinical trials for this centre