Alfried Krupp Krankenhaus, ALS outpatient clinic

Our outpatient clinic at Alfried Krupp Krankenhaus, Essen, provides diagnosis and multidisciplinary care to around 500 patients with ALS and related motoneuron diseases. Our clinical research currently focuses on managed care, shared decison making (SDM) and palliative care. The ALS outpatient clinic cooperates with the ALS management platform AmbulanzPartner (www.ambulanzpartner.de).

Alfried Krupp Krankenhaus, ALS outpatient clinic
Foundation year

2016

Director

Prof. Dr. med. Peter Berlit

Principal investigator

Dr. med. Torsten Grehl

Contact information
Address

Alfried-Krupp-Straße 21
45131, Essen
Germany

Contact

Dr. med. Torsten Grehl

Phone

+49(0)201-4342913

Fax

+49(0)201-4342377

Email torsten.grehl@rub.de
Website Visit the website

Publications

  • Dorst, J., et al. (2015). “Percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis: a prospective observational study.” J Neurol 262(4): 849-858.
  • Gerardo-Nava, J., et al. (2014). “Spinal cord organotypic slice cultures for the study of regenerating motor axon interactions with 3D scaffolds.” Biomaterials 35(14): 4288-4296.
  • Grehl, T. (2013). “[Diagnostics and therapy for amyotrophic lateral sclerosis].” Fortschr Neurol Psychiatr 81(10): 592-603;
  • Gerardo-Nava, J., et al. (2013). “Differential pattern of neuroprotection in lumbar, cervical and thoracic spinal cord segments in an organotypic rat model of glutamate-induced excitotoxicity.” J Chem Neuroanat 53: 11-17.
  • Synofzik, M., et al. (2012). “Screening in ALS and FTD patients reveals 3 novel UBQLN2 mutations outside the PXX domain and a pure FTD phenotype.” Neurobiol Aging 33(12): 2949 e2913-2947.

Restricted information

Serving population
Serving population

1.000.0000 or more

Patient resources
Population based register

Yes

Clinic based register

Yes

Geographically matched controls

No

Number of skin samples

80

Number of IPS cell samples

5

Banks

Type ALS Patients Controls Other
DNA Bank 370 100 0
Serum Bank 370 100 50
Research activities
Clinical management research

Yes

Neuro epidemiology

Yes

Neuro physiology

Yes

Neuro imaging

Yes

Neuro psychology

Yes

Neuro pathology

Yes

Genomics

No

Transcriptomics

No

Metabolomics

No

Clinical Trials - Industry sponsored

Name Type Patients
RAS-ALS , 2013, Eudra CT 2011-004482-32 RAS-ALS , 2013, Eudra CT 2011-004482-32 10
NOG112264; Eudra CT 2012-003349-13 NOG112264; Eudra CT 2012-003349-13 10
ENVISION 2012; Eudra CT 2011-006119-70 ENVISION 2012; Eudra CT 2011-006119-70 20
EMPOWER 2011; Eudra CT 2010-022818-19 EMPOWER 2011; Eudra CT 2010-022818-19 20
ALS-TAL201 2009; Eudra CT 2008-002062-62 ALS-TAL201 2009; Eudra CT 2008-002062-62 20
SIRONA 2007; Eudra CT 2007-004723-37 SIRONA 2007; Eudra CT 2007-004723-37 18
ALS-GA-201 2006; Eudra CT 2006-00168-49 ALS-GA-201 2006; Eudra CT 2006-00168-49 22

Clinical Trials - Investigator initiated

Name Type Patients
LIPCAL-ALS, NCT02306590, high calorie dietary LIPCAL-ALS, NCT02306590, high calorie dietary 15
GERP 2009; Eudra CT 2006-005410-13 GERP 2009; Eudra CT 2006-005410-13 15