Care Missions
- Consultation of recourse for MND
- Management of MND patients from diagnosis to last stages
- Quaterly Multidisciplinary follow-up of MND patients
- Coordonation of medical, paramedical and social support at home in collaboration with the NeuroCentre Networ
Research
Genetics
- Identification of susceptibility factors of ALS
- Setup of next generation sequencing
Biomarkers
- Identification of CSF and blood biomarkers for the diagnostic and the pronostic of ALS using metabolomics
- Energetic metabolism exploration (calorimetry, functional exploration of fibroblasts…) : ongoing
Clinical Trials
- Contribution to clinical trials
- Development of pharmacogenomics
We are also developing scientific projects on Molecular Imaging focused on neuro-inflammation.
We are setting-up a ALS Registry in the Centre Val de Loire which is an extension of the Registry of the Limousin
Communications and Publications of the results of our studies during French and International ALS Meeting and into national and international reviews.
| ALS Centre CHU Bretonneau | |
|---|---|
| Foundation year | 2003 |
| Director | Prof. Philippe Corcia |
| Principal investigator | Prof. Philippe Corcia |
| Contact information | |
|---|---|
| Address | ALS Centre |
| Contact | Prof. Philippe Corcia |
| Phone | +33247474747 ext 70332. Secretary: +33247473724 |
| corcia@med.univ-tours.fr | |
Publications
Restricted information
| Patient resources | |
|---|---|
| Population based register | No |
| Clinic based register | Yes |
| Geographically matched controls | Yes |
Banks
| Type | ALS Patients | Controls | Other |
|---|---|---|---|
| DNA bank | 1000 | 400 | |
| Serum bank | 50 | 30 | |
| RNA bank | |||
| LCR bank | 50 | 100 | |
| Muscle bank | 10 | 20 |
| Research activities | |
|---|---|
| Clinical management research | No |
| Neuro epidemiology | Yes |
| Neuro physiology | No |
| Neuro imaging | No |
| Neuro psychology | No |
| Neuro pathology | No |
| Genomics | Yes |
| Transcriptomics | No |
| Metabolomics | Yes |
Clinical Trials - Industry sponsored
| Name | Type | Patients |
|---|---|---|
| Cy4031 | Therapeutic | |
| MIROCALS (in process) | ||
| TUDCA-H2020 (in process) | ||
| ROCK-ALS (in process) |
Clinical Trials - Investigator initiated
| Name | Type | Patients |
|---|---|---|
| Pulse | Observational | 1 |
| NUTRALS | Therapeutic | 18 |