The ALS-Clinic in Lisbon has initiated its activities in 1985. Since then has been devoted to the care of ALS patients, mostly from Lisbon area, but also to many patients living in other regions of the country. In addition to clinical activities this center has been doing continous clinical and neurophysiological research, in particular on electrophysiological diagnosis, measurement of disease progression, and respiratory changes and its treatment. More recently, we have develloped other areas of research, as molecular biomarkers.
| ALS CLINIC – LISBON (Centro Hospitalar Lisboa) | |
|---|---|
| Foundation year | 1983 |
| Director | Mamede de Carvalho |
| Principal investigator | Mamede de Carvalho |
| Contact information | |
|---|---|
| Address | Department of Neurosciences and Mental Health, Centro Hospitalar |
| Contact | Prof Mamede de Carvalho |
| Phone | + 351 21 7805219 |
| Fax | + 351 21 7805219 |
| mamedemg@netcabo.pt | |
Publications
- De Carvalho, M., Turkman, A., Pinto, S., Swash, M. (2016). Modulation of fasciculation frequency in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 87:226-228.
- Pinto, S., Alves, P., Pimentel, B., Swash, M., de Carvalho, M (2016). Ultrasound for assessment of diaphragm in ALS. Clin Neurophysiol 127:892-897.
- Londral, A., Pinto, A., Pinto, S., Azevedo, L., de Carvalho, M. (2016). Markers for upper limb dysfunction in Amyotrophic Lateral Sclerosis using analysis of typing activity. Clin Neurophysiol 127: 925-931.
- Costa, J., de Carvalho, M. (2016). Emerging molecular biomarker targets for amyotrophic lateral sclerosis. Clin Chim Acta 455: 7-14
- De Carvalho, M., Swash, M. (2016). Lower motor neuron dysfunction in ALS. Clin Neurophysiol 127:2670-2681.
Find more publications of Prof Mamede de Carvalho via PubMed.
Restricted information
| Serving population | |
|---|---|
| Serving population | 3.000.000 |
| Patient resources | |
|---|---|
| Population based register | No |
| Clinic based register | Yes |
| Geographically matched controls | Yes |
Banks
| Type | ALS Patients | Controls | Other |
|---|---|---|---|
| Plasma | 200 | 100 | |
| CSF Biobank | 80 | 50 |
| Research activities | |
|---|---|
| Clinical management research | Yes |
| Neuro epidemiology | No |
| Neuro physiology | Yes |
| Neuro imaging | Yes |
| Neuro psychology | No |
| Neuro pathology | No |
| Genomics | Yes |
| Transcriptomics | No |
| Metabolomics | Yes |
Clinical Trials - Industry sponsored
| Name | Type | Patients |
|---|---|---|
| Combination with riluzole in the treatment of patients suffering from ALS | AB10015 (2016-2017) | 3 |
| Ventilatory investigation of tirasemtiv and assessment of longitudinal after treatment for a year | Vitality (2016-2017) | 5 |
Clinical Trials - Investigator initiated
There are no clinical trials for this centre