The newly stablished ALS multidisciplinary clinic (UMELA) in San Sebastián undertakes and oversees the overall care of patients with MND in the Guipúzcoa region (Basque Country, Spain). Furthermore, referrals for expert opinion from other regions in the Basque Country and nearby communities are received. The UMELA is part of the Neuromuscular Clinic based at Hospital Universitario Donostia, with more than 25 years of experience in attending and caring for patients with neuromuscular diseases. The ALS clinic is attended by neurologists, a specialized MND nurse, physio, speech and occupational therapists, nutritionists, pneumologists, palliative doctors and neurophysiologists.
An active ALS research group in Biodonostia Health Research Institute aims to contribute to the understanding of the pathophysiology of ALS, the discovery of biomarkers and the development of new therapeutic strategies. This ALS research group is integrated in the Spanish Neurodegenerative Diseases Network (CIBERNED) and Basque Biobank, and has several collaborations with other national and international MND research groups.
| ALS multidisciplinary clinic (UMELA), Hospital Universitario Donostia | |
|---|---|
| Foundation year | 2018 |
| Director | Prof. Adolfo López de Munain |
| Principal investigator | Prof. Adolfo López de Munain |
| Contact information | |
|---|---|
| Address | Doctor Beguiristain 109, |
| Contact | Karmele ARNAIZ |
| Phone | +34 943 006295 |
| Mirenkarmele.arnaizperez@osakidetza.eus | |
| Website | Visit the website |
Publications
- Riancho J, Gil-Bea FJ, López de Munaín A. Retinoids and Amyotrophic Lateral Sclerosis. JAMA Neurology (2018)1;75(9):1153
- Dols-Icardo O, Nebot I, Gorostidi A, Ortega-Cubero S, Hernández I, Rojas-Garcia R, García-Redondo A, Povedano M, Lladó A, Álvarez V, Sánchez-Juan P, Prdo J, Jericó I, Vázquez-Costa J, Sevilla, T, Cardona F, Indakoechea B, Moreno F, Fernández-Torrón R, Muñoz-Llahuna L, Moreno-Grau S, Rosende-Roca M, Vela A, Muñoz-Blñanco JL, Combarros O, Coto E, Alcolea D, Fortea J, Lleó A, Sánchez-Valle R, Esteban-Pérez J, Ruiz A, Pastor P, López de Munain A, Pérez-Tur J, Clarimón J; dementia Geneticas Spanish Consortium (DEGESCO). Analysis of the CHCHD10 gene in patients with frontotemporal dementia and amyotrophic lateral sclerosis from Spain. Brain (2015)138(Pt12):e400
- García-Redondo A, Dols-Icardo O, Rojas-García R, Esteban-Pérez J, Cordero-Vázquez P, Muñoz-Blanco JL, Catalina I, González-Muñoz M, Varona L, Sarasola E, Povedano M, Sevilla T, Guerrero A, Pardo J, López de Munain A, Márquez-Infante C, de Rivera FJ, Pastor P, Jericó I, de Arcaya AÁ, Mora JS, Clarimón J; C9ORF72 Spanish Study Group, Gonzalo-Martínez JF, Juárez-Rufián A, Atencia G, Jiménez-Bautista R, Morán Y, Mascías J, Hernández-Barral M, Kapetanovic S, García-Barcina M, Alcalá C, Vela A, Ramírez-Ramos C, Galán L, Pérez-Tur J, Quintáns B, Sobrido MJ, Fernández-Torrón R, Poza JJ, Gorostidi A, Paradas C, Villoslada P, Larrodé P, Capablo JL, Pascual-Calvet J, Goñi M, Morgado Y, Guitart M, Moreno-Laguna S, Rueda A, Martín-Estefanía C, Cemillán C, Blesa R, Lleó A. Analysis of the C9orf72 gene in patients with amyotrophic lateral sclerosis in Spain and different populations qorldwide. Hum Mutat. (2013)34(1):79-82
- Riancho J, Gil-Bea FJ, Castanedo-Vazquez D, Sedano MJ, Zufiría M, de Eulate GFG, Poza JJ, de Munain AL. Clinical evidences supporting the Scr/c-Abl pathway as potential therapeutic target in amyotrophic lateral sclerosis. J Neurol Sci (2018)15393:80-82
- Zufiria M, Gil-Bea FJ, Fernández-Torrón R, Poza JJ, Muñoz-Blanco JL, Rojas-García R, Riancho J, de Munain AL. ALS: A bucket of genes, enviroment, metabolism and unkown ingredients. Prog Neurobiol (2016)142:104-29
Restricted information
| Serving population | |
|---|---|
| Serving population | 700.000 |
| Patient resources | |
|---|---|
| Population based register | No |
| Clinic based register | Yes |
| Geographically matched controls | No |
| Number of skin samples | 10 |
| Number of spinal cord samples | 10 |
| Number of brain samples | 10 |
| Number of IPS cell samples | 1-2 |
Banks
| Type | ALS Patients | Controls | Other |
|---|---|---|---|
| DNA Bank | 150 | 300 | |
| Serum Bank | 60 | 100 | |
| RNA Bank | 100 | 100 |
| Research activities | |
|---|---|
| Clinical management research | Yes |
| Neuro epidemiology | No |
| Neuro physiology | Yes |
| Neuro imaging | Yes |
| Neuro psychology | Yes |
| Neuro pathology | Yes |
| Genomics | Yes |
| Transcriptomics | Yes |
| Metabolomics | Yes |
Clinical Trials - Industry sponsored
There are no clinical trials for this centre
Clinical Trials - Investigator initiated
There are no clinical trials for this centre