ALS Centre Brescia

Center for Neuromuscular Diseases, Unit of Neurology, ASST “Spedali Civili” and University of Brescia.

ALS Centre Brescia
Foundation year

2004

Director

Prof. Alessandro Padovani (Unit of Neurology)

Principal investigator

Dr. Massimiliano Filosto (Head of Center for Neuromuscular Diseases)

Contact information
Address

P.le Spedali Civili 1
25100 Brescia
Italy

Contact

Dr. Massimiliano Filosto

Phone

00390303995632

Email massimiliano.filosto@unibs.it
Website Visit the website

Publications

  • Maggi L, Ravaglia S, Farinato A, Brugnoni R, Altamura C, Imbrici P, Camerino DC, Padovani A, Mantegazza R, Bernasconi P, Desaphy JF, Filosto M.Coexistence of CLCN1 and SCN4A mutations in one family suffering from myotonia. Neurogenetics. 2017 Dec;18(4):219-225;
  • Bella ED, Tramacere I, Antonini G, Borghero G, Capasso M, Caponnetto C, Chiò A, Corbo M, Eleopra R, Filosto M, Giannini F, Granieri E, Bella V, Lunetta C, Mandrioli J, Mazzini L, Messina S, Monsurrò MR, Mora G, Riva N, Rizzi R, Siciliano G, Silani V, Simone I, Sorarù G, Volanti P, Lauria G. Protein misfolding, amyotrophic lateral sclerosis and guanabenz: protocol for a phase II RCT with futility design (ProMISe trial).BMJ Open. 2017 Aug 11;7(8):e015434
  • Biasiotto G, Archetti S, Di Lorenzo D, Merola F, Paiardi G, Borroni B, Alberici A, Padovani A, Filosto M, Bonvicini C, Caimi L, Zanella I.A PCR-based protocol to accurately size C9orf72 intermediate-length alleles.Mol Cell Probes. 2017 Apr;32:60-64
  • Pilotto A, Rossi F, Rinaldi F, Compostella S, Cosseddu M, Borroni B, Filosto M, Padovani A.Exploring Olfactory Function and Its Relation with Behavioral and Cognitive Impairment in Amyotrophic Lateral Sclerosis Patients: A Cross-Sectional Study.Neurodegener Dis. 2016;16(5-6):411-6.
  • Filosto M, Aureli M, Castellotti B, Rinaldi F, Schiumarini D, Valsecchi M, Lualdi S, Mazzotti R, Pensato V, Rota S, Gellera C, Filocamo M, Padovani A.ASAH1 variant causing a mild SMA phenotype with no myoclonic epilepsy: a clinical, biochemical and molecular study. Eur J Hum Genet. 2016 Nov;24(11):1578-1583.

Restricted information

Serving population
Serving population

East Lombardy, Italy

Patient resources
Population based register

No

Clinic based register

Yes

Geographically matched controls

Yes

Banks

Type ALS Patients Controls Other
DNA Bank
Serum Bank
RNA Bank 0 0
Research activities
Clinical management research

Yes

Neuro epidemiology

No

Neuro physiology

Yes

Neuro imaging

Yes

Neuro psychology

Yes

Neuro pathology

Yes

Genomics

Yes

Transcriptomics

No

Metabolomics

No

Clinical Trials - Industry sponsored

There are no clinical trials for this centre

Clinical Trials - Investigator initiated

  • “Genetic and environmental predictors of early onset of Amyotrophic Lateral Sclerosis”. Coordinator Dr. E. Beghi, Istituto di Ricerche Farmacologiche “Mario Negri”, Milano;
  • “Multicenter, randomized, double blind study on effects of combined use of litium salt and riluzole in ALS”. Coordinator Dr. M. Pocchiari, Istituto Superiore di Sanità, Roma;
  • ”Euromotor European Mutidisciplinary ALS network identification to cure motor neuron de generation” (FP/72007-2013). Coordinator Dr. A. Chiò, Università di Torino;
  • “Amyotrophic Lateral Sclerosis, sport, physical activity and trauma: an international case-control study on genetic and environmental risk factors”. Coordinator Dr. E. Beghi, Istituto di Ricerche Farmacologiche “Mario Negri”, Milano;
  • “Safety and efficacy of erythropoietin in amyotrophic lateral sclerosis: a randomized, placebo-controlled clinical trial”. Coordinator Dr. G. Lauria, IRCCS Fondazione Istituto Neurologico “Carlo Besta” Milano;
  • “Protein misfolding Amyotrophic Lateral Sclerosis and guanabenz, a phase II RCT with futility design“. PROMISE, Coordinator. Dr. G. Lauria – Milano  – Eudract:2014-005367-32;
  • “The effects of RNS60 on ALS biomarkers“. Coordinator Dr. E. Beghi, Istituto Mario Negri, Milano;
  • “Translating molecular mechanisms into ALS risk and patient’s well-being (TRANS-ALS)”. FRRB Lombardy Call 2015 (Fondazione Regionale per la Ricerca Biomedica), Coordinator Dr. G. Lauria, IRCCS Fondazione Istituto Neurologico “Carlo Besta” Milano.
Name Type Patients
Genetic and environmental predictors of early onset of Amyotrophic Lateral Sclerosis Coordinator Dr. E. Beghi, Istituto di Ricerche Farmacologiche “Mario Negri”, Milano;
Multicenter, randomized, double blind study on effects of combined use of litium salt and riluzole in ALS Coordinator Dr. M. Pocchiari, Istituto Superiore di Sanità, Roma
Euromotor European Mutidisciplinary ALS network identification to cure motor neuron de generation (FP/72007-2013) Coordinator Dr. A. Chiò, Università di Torino
Amyotrophic Lateral Sclerosis, sport, physical activity and trauma: an international case-control study on genetic and environmental risk factors Coordinator Dr. E. Beghi, Istituto di Ricerche Farmacologiche “Mario Negri”, Milano
Safety and efficacy of erythropoietin in amyotrophic lateral sclerosis: a randomized, placebo-controlled clinical trial Coordinator Dr. G. Lauria, IRCCS Fondazione Istituto Neurologico “Carlo Besta” Milano
Protein misfolding Amyotrophic Lateral Sclerosis and guanabenz, a phase II RCT with futility design PROMISE, Coordinator. Dr. G. Lauria, Milano
The effects of RNS60 on ALS biomarkers Coordinator Dr. E. Beghi, Istituto Mario Negri, Milano
Translating molecular mechanisms into ALS risk and patient’s well-being (TRANS-ALS) FRRB Lombardy Call 2015 (Fondazione Regionale per la Ricerca Biomedica), Coordinator Dr. G. Lauria, IRCCS Fondazione Istituto Neurologico “Carlo Besta” Milano.