ALS Centre Brescia

Department of Clinical and Experimental Sciences, University of Brescia; Unit of Neurology, ASST “Spedali Civili”, Brescia; NeMO-Brescia Clinical Center for Neuromuscular Diseases

ALS Centre Brescia
Foundation year

2004
Director

Prof. Alessandro Padovani (Unit of Neurology), Prof. Massimiliano Filosto (NeMO-Brescia Clinical Center for Neuromuscular Diseases)
Principal investigator

Prof. Alessandro Padovani Prof. Massimiliano Filosto
Contact information
Address

P.le Spedali Civili 1, 25100 Brescia
Via P. Richiedei 16, 25 25064 Gussago, Brescia
Italy
Contact

Prof. Alessandro Padovani, Prof. Massimiliano Filosto
Phone

0039 0306729100 / 0039 0303995632
Email massimiliano.filosto@unibs.it
Website Visit the website

Publications

  • S. Cotti Piccinelli, MT Bassi, A. Citterio, F. Manganelli, S. Tozza, FM Santorelli, S. Gallo Cassarino, F. Caria, E. Baldelli, A. Galvagni, L. Santoro, A. Padovani, M. Filosto. A novel CAPN1 mutation causes a pure hereditary spastic paraplegia in an italian family. Front Neurol (2019) 10: 580
  • A. Benussi, A. Alberici, MS Cotelli, V. Dell’Era, V. Cantoni, E. Bonetta, R. Manenti, M. Filosto, R. Morini, A. Datta, C. Thomas, S. Vucic, A. Padovani, B. Borroni. Cortico-spinal tDCS in ALS: a randomized, double-blind, sham-controlled trial. Brain Stimul (2019) 12: 1332-1334
  • M. Gobbo, S. Lazzarini, L. Vacchi, P. Gaffurini, L. Bissolotti, A. Padovani, M. Filosto. Exercise combined with electrotherapy enhances motor function in an adolescent with spinal muscular atrophy type III: a case report. Case Rep Neurol Med (2019) article ID 4839793
  • F. Caria, M. Cescon, F. Gualandi, A. Pichiecchio, R. Rossi, P. Rimessi, S. Cotti Piccinelli, S. Gallo Cassarino, I. Gregorio, A. Galvagni, A. Ferlini, A. Padovani, P. Bonaldo, M. Filosto. Autosomal recessive Bethlem myopathy: a clinical, genetic and functional study. Neuromuscul Disord (2019) 29: 657-663
  • S. Cotti Piccinelli, G. Carella, M. Frassi, F. Caria, S. Gallo Cassarino, E. Baldelli, M. Marini, A- Tincani, A. Padovani, M. Filosto. Human leukocyte antigens class II in CIDP spectrum neuropathies. J Neurol Sci (2019) 15; 407:116533
  • A. Benussi, A. Pilotto, E. Premi, I. Libri, M. Giunta, C. Agosti, A. Alberici, E. Baldelli, M. Benini, S. Bonacina, L. Brambilla, S. Caratozzolo, M. Cortinovis, A. Costa, S. Cotti Piccinelli, E. Cottini, V. Cristillo, I. Delrio, M. Filosto, M. Gamba, S. Gazzina, N. Gilberti, S. Gipponi, A. Imarisio, P. Invernizzi, U. Leggio, M. Leonardi, P. Liberini, M. Locatelli, S. Masciocchi, L. Poli, R. Rao, B. Risi, L. Rozzini, A. Scalvini, F. Schiano di Cola, R. Spezi, V. Vergani, I. Volonghi, N. Zoppi, B. Borroni, M. Magoni, A. Pezzini, A. Padovani. Clinical characteristics and outcomes of inpatients with neurological disease and COVID-19. Neurology (2020) 95: e910-e920

Restricted information

Serving population
Serving population

East Lombardy, Italy
Patient resources
Population based register

No
Clinic based register

Yes
Geographically matched controls

Yes

Banks

Type ALS Patients Controls Other
DNA Bank
Serum Bank
RNA Bank 0 0
Research activities
Clinical management research

Yes
Neuro epidemiology

No
Neuro physiology

Yes
Neuro imaging

Yes
Neuro psychology

Yes
Neuro pathology

Yes
Genomics

Yes
Transcriptomics

No
Metabolomics

No

Clinical Trials - Industry sponsored

There are no clinical trials for this centre

Clinical Trials - Investigator initiated

  • “Genetic and environmental predictors of early onset of Amyotrophic Lateral Sclerosis”. Coordinator Dr. E. Beghi, Istituto di Ricerche Farmacologiche “Mario Negri”, Milano;
  • “Multicenter, randomized, double blind study on effects of combined use of litium salt and riluzole in ALS”. Coordinator Dr. M. Pocchiari, Istituto Superiore di Sanità, Roma;
  • ”Euromotor European Mutidisciplinary ALS network identification to cure motor neuron de generation” (FP/72007-2013). Coordinator Dr. A. Chiò, Università di Torino;
  • “Amyotrophic Lateral Sclerosis, sport, physical activity and trauma: an international case-control study on genetic and environmental risk factors”. Coordinator Dr. E. Beghi, Istituto di Ricerche Farmacologiche “Mario Negri”, Milano;
  • “Safety and efficacy of erythropoietin in amyotrophic lateral sclerosis: a randomized, placebo-controlled clinical trial”. Coordinator Dr. G. Lauria, IRCCS Fondazione Istituto Neurologico “Carlo Besta” Milano;
  • “Protein misfolding Amyotrophic Lateral Sclerosis and guanabenz, a phase II RCT with futility design“. PROMISE, Coordinator. Dr. G. Lauria – Milano  – Eudract:2014-005367-32;
  • “The effects of RNS60 on ALS biomarkers“. Coordinator Dr. E. Beghi, Istituto Mario Negri, Milano;
  • “Translating molecular mechanisms into ALS risk and patient’s well-being (TRANS-ALS)”. FRRB Lombardy Call 2015 (Fondazione Regionale per la Ricerca Biomedica), Coordinator Dr. G. Lauria, IRCCS Fondazione Istituto Neurologico “Carlo Besta” Milano.
Name Type Patients
Genetic and environmental predictors of early onset of Amyotrophic Lateral Sclerosis Coordinator Dr. E. Beghi, Istituto di Ricerche Farmacologiche “Mario Negri”, Milano;
Multicenter, randomized, double blind study on effects of combined use of litium salt and riluzole in ALS Coordinator Dr. M. Pocchiari, Istituto Superiore di Sanità, Roma
Euromotor European Mutidisciplinary ALS network identification to cure motor neuron de generation (FP/72007-2013) Coordinator Dr. A. Chiò, Università di Torino
Amyotrophic Lateral Sclerosis, sport, physical activity and trauma: an international case-control study on genetic and environmental risk factors Coordinator Dr. E. Beghi, Istituto di Ricerche Farmacologiche “Mario Negri”, Milano
Safety and efficacy of erythropoietin in amyotrophic lateral sclerosis: a randomized, placebo-controlled clinical trial Coordinator Dr. G. Lauria, IRCCS Fondazione Istituto Neurologico “Carlo Besta” Milano
Protein misfolding Amyotrophic Lateral Sclerosis and guanabenz, a phase II RCT with futility design PROMISE, Coordinator. Dr. G. Lauria, Milano
The effects of RNS60 on ALS biomarkers Coordinator Dr. E. Beghi, Istituto Mario Negri, Milano
Translating molecular mechanisms into ALS risk and patient’s well-being (TRANS-ALS) FRRB Lombardy Call 2015 (Fondazione Regionale per la Ricerca Biomedica), Coordinator Dr. G. Lauria, IRCCS Fondazione Istituto Neurologico “Carlo Besta” Milano.