Novara ALS Centre – University Hospital Maggiore della Carità

The tertiary ALS Centre is located at the University Hospital “Maggiore della Carità” in Novara and represents a national and international reference Centre for the diagnosis, treatment and clinical research of motor neuron diseases. It offers a multi- and interdisciplinary approach including all the facilities for diagnosis, treatment and care. Each year more than 400 patients (200 new patients) coming from all Italian regions and some neighboring European countries are visited in the Centre for diagnosis and treatment.

All patients are cared  by a multidisciplinary team that is made up of different disciplines (doctors, nurses, therapists, psychologist) working in a co-ordinated and organised manner. The Centre also provides consultancy and support to doctors of the NHS, educational activities for health workers and volunteers, information to patients and associations about the disease and treatment.

The Center participates in the definition of clinical protocols for the diagnosis and management  with other national  and  international organizations.

The Centre has the structure, the expertise, the facilities, and the qualified personnel needed to conduct all clinical trials. The scientific interest is in translational research for ALS. The Centre has actively taken part in the foundation and updating of the first Italian population-based register in Piedmont. Another topic of the scientific activity is the research of new genes responsible for the familial or sporadic form of MND and FTD. A DNA bank has been implemented and stored the DNA samples from a cohort of 1000 ALS patients fully characterized clinically and for mutations in associated genes. The centre cooperates as coordinator or Participating Centre in many national and international multicenter therapeutic trials in ALS.

Novara ALS Centre – University Hospital Maggiore della Carità
Foundation year

2004

Director

Letizia Mazzini

Principal investigator

Letizia Mazzini, Fabiola De Marchi

Contact information
Address

Corso Mazzini 18
28100 Novara, Italy

Contact

Letizia Mazzini / Fabiola De Marchi

Phone

0039 0321 3733962

Email ambulatorioslanovara@tiscali.it
Website Visit the website

Publications

Restricted information

Serving population
Serving population

Italian patients

Patient resources
Population based register

Yes

Clinic based register

Yes

Geographically matched controls

Yes

Number of skin samples

10

Number of IPS cell samples

5

Banks

Type ALS Patients Controls Other
DNA Bank 1000 1000
Serum Bank 1000 1000
RNA Bank 0 0
Research activities
Clinical management research

Yes

Neuro epidemiology

Yes

Neuro physiology

Yes

Neuro imaging

Yes

Neuro psychology

Yes

Neuro pathology

No

Genomics

Yes

Transcriptomics

Yes

Metabolomics

Yes

Clinical Trials - Industry sponsored

Name Type Patients
REFALS Phase III 9

Clinical Trials - Investigator initiated

Name Type Patients
RNS60 (Coordinator Centre) Phase II 20
RAPALS Phase II 10