Clinical Centre for Neuromuscular Diseases-Azienda Ospedaliero-Universitaria Pisana

Since a long time, our Centre is the referral Centre for the entire North-West Tuscany and one of the most important Centre in Tuscany.

The Center belongs to ERN Euro-NMD, and it is considered as a national reference Centre for care of Motor Neuron Diseases.

Clinical Centre for Neuromuscular Diseases-Azienda Ospedaliero-Universitaria Pisana
Foundation year



Prof.Gabrielle Siciliano

Principal investigator

Prof. Gabrielle Sciliano

Contact information

Via Roma 67, 56100 Pisa, Italy


Prof. Gabriele Siciliano, Dott.ssa Francesca Bianchi



Website Visit the website


  1. Beghi E, Pupillo E, Bianchi E, Bonetto V, Luotti S, Pasetto L, Bendotti C, Tortarolo M, Sironi F, Camporeale L, Sherman AV, Paganoni S, Scognamiglio A, De Marchi F, Bongioanni P, Del Carratore R, Caponnetto C, Diamanti L, Martinelli D, Calvo A, Filosto M, Padovani A, Piccinelli SC, Ricci C, Dalla Giacoma S, De Angelis N, Inghilleri M, Spataro R, La Bella V, Logroscino G, Lunetta C, Tarlarini C, Mandrioli J, Martinelli I, Simonini C, Zucchi E, Monsurrò MR, Ricciardi D, Trojsi F, Riva N, Filippi M, Simone IL, Sorarù G, Spera C, Florio L, Messina S, Russo M, Siciliano G, Conte A, Saddi MV, Carboni N, Mazzini L; RNS60-ALS Study Group. Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial. Eur J Neurol. 2023 Jan;30(1):69-86.doi: 10.1111/ene.15573. Epub 2022 Oct 7.
  2. Donatelli G, Costagli M, Cecchi P, Migaleddu G, Bianchi F, Frumento P, Siciliano G, Cosottini M. Motor cortical patterns of upper motor neuron pathology in amyotrophic lateral sclerosis: A 3 T MRI study with iron-sensitive sequences. Neuroimage Clin2022;35:103138. doi: 10.1016/j.nicl.2022.103138. Epub 2022 Jul 29.
  3. Cosottini M, Donatelli G, Ricca I, Bianchi F, Frosini D, Montano V, Migaleddu G, Del Prete E, Tessa A, Cecchi P, D’Amelio C, Siciliano G, Mancuso M, Santorelli FM.
    Iron-sensitive MR imaging of the primary motor cortex to differentiate hereditary spastic paraplegia from other motor neuron diseases. Eur Radiol2022 Dec;32(12):8058-8064. doi: 10.1007/s00330-022-08865-6. Epub 2022 May 20.
  4. Costagli M, Donatelli G, Cecchi P, Bosco P, Migaleddu G, Siciliano G, Cosottini M. Distribution Indices of Magnetic Susceptibility Values in the Primary Motor Cortex Enable to Classify Patients with Amyotrophic Lateral Sclerosis.
    Brain Sci2022 Jul 18;12(7):942. doi: 10.3390/brainsci12070942.
  5. Diamanti L, Borrelli P, Dubbioso R, Capasso M, Morelli C, Lunetta C, Petrucci A, Mora G, Volanti P, Inghilleri M, Tremolizzo L, Mandrioli J, Mazzini L, Vedovello M, Siciliano G, Filosto M, Matà S, Montomoli C; DYALS Study Group. Validation of the DYALS (dysphagia in amyotrophic lateral sclerosis) questionnaire for the evaluation of dysphagia in ALS patients. Neurol Sci . 2022 May;43(5):3195-3200. doi: 10.1007/s10072-021-05775-1. Epub 2021 Dec 1.


Restricted information

Serving population
Serving population

Our patients come from different places across Tuscany. We are the referring Centre for North-west Tuscany and one of the most important Centre in Tuscany and in Central Italy. Patients coming from other regions of Central and South Italy often require an evaluation in our Centre to achieve a second opinion on diagnosis.

Patient resources
Population based register


Clinic based register


Geographically matched controls



Type ALS Patients Controls Other
DNA bank 150 0 0
Serum bank 150 0 0
RNA bank 10 0 0
Research activities
Clinical management research


Neuro epidemiology


Neuro physiology


Neuro imaging


Neuro psychology


Neuro pathology








Clinical Trials - Industry sponsored

Name Type Patients
Evaluation of changes in oxidative-stress related parameters during the intake of mixed natural plant extracts, including curcumin (Aliveda) Inventional 84

Clinical Trials - Investigator initiated

Name Type Patients
Cognitive Profile Evaluation in time of different clinical phenotypes of ALS Observational Study 80
Multiparametric Assessement of Early Respiratory Involvement in ALS Observational Study 70
SOD1 nei pazienti SLA italiani: uno studio a livello nazionale Observational Study 10
Multimodal Intelligent Methods for Orofacial and Speech Assessment to Predict ALS Bulbar Decline Observational Study 50