The ALS Centre at IRCCS Ospedale Policlinico San Martino is the regional referral Centre for ALS and other motor neuron diseases (MNDs) in Liguria, Italy. The structure includes in and out-patient fully equipped clinics staffed by a multidisciplinary team of experts constantly involved in early diagnosis, management and treatment of MNDs. To successfully pursue these objectives the Centre has adopted a multimodal translational research approach integrating clinical, genetic, MRI, cognitive and biofluid markers.
| IRCCS Ospedale Policlinico San Martino | |
|---|---|
| Foundation year | 1923 |
| Director | Dr. Chiara Gemelli |
| Principal investigator | Dr. Pilar M. Ferraro, Dr. Chiara Gemelli |
| Contact information | |
|---|---|
| Address | Largo P. Daneo 3 |
| Contact | Dr. Pilar M. Ferraro, Dr. Chiara Gemelli |
| Phone | 0039 010 555 7290 |
| pilarmariaferraro@gmail.com, chiara.gemelli@hsanmartino.it | |
| Website | Visit the website |
Publications
- Cabona C, Ferraro PM, Meo G, Roccatagliata L, Schenone A, Inglese M, Villani F, Caponnetto C. Predictors of self-perceived health worsening over COVID-19 emergency in ALS. Neurol Sci. 2021. doi: 10.1007/s10072-020-04997-z.
- Ferraro PM, Cabona C, Meo G, Rolla-Bigliani C, Castellan L, Pardini M, Inglese M, Caponnetto C, Roccatagliata L. Age at symptom onset influences cortical thinning distribution and survival in Amyotrophic Lateral Sclerosis. Neuroradiology 2021. doi:10.1007/s00234-021-02681-3.
- Ferraro PM, Campi C, Miceli A, Rolla-Bigliani C, Bauckneht M, Gualco L, Piana M, Marini C, Castellan L, Morbelli S, Caponnetto C, Sambuceti G, Roccatagliata L. 18 F-FDG-PET correlates of aging and disease course in ALS as revealed by distinct PVC approaches. DOI: 10.1016/j.ejro.2022.100394
- Reply to “Cognition and motor phenotypes in ALS: a retrospective study”. Ferraro PM, Ponzano M, Cillerai M, Signori A, Caponnetto C. Neurol Sci. 2023 Dec;44(12):4531-4533. doi: 10.1007/s10072-023-06976-6. Epub 2023 Jul 31.
- MND Phenotypes Differentiation: The Role of Multimodal Characterization at the Time of Diagnosis. Meo G, Ferraro PM, Cillerai M, Gemelli C, Cabona C, Zaottini F, Roccatagliata L, Villani F, Schenone A, Caponnetto C.Life (Basel). 2022 Sep 27;12(10):1506. doi: 10.3390/life12101506.
- Clinical epidemiology of amyotrophic lateral sclerosis in Liguria, Italy: a ten year follow up study. Cabona C, Ferraro PM, Scialò C, Bandettini Di Poggio M, Novi G, Gemelli C, Vignolo M, Rao F, Capovilla M, Marogna M, Mandich P, Origone P, Schenone A, Caponnetto C. Amyotroph Lateral Scler Frontotemporal Degener. 2023 Sep 22:1-8. doi: 10.1080/21678421.2023.2260842.
- Mild behavioral impairment as a potential marker of predementia risk states in motor neuron diseases Ferraro PM, Gervino E, De Maria E, Meo G, Ponzano M, Pardini M, Signori A, Schenone A, Roccatagliata L, Caponnetto C.Eur J Neurol. 2023 Jan;30(1):47-56. doi: 10.1111/ene.15570. Epub 2022 Oct 2.MND Phenotypes Differentiation: The Role of Multimodal Characterization at the Time of Diagnosis
Restricted information
| Serving population | |
|---|---|
| Serving population | 1.500.000 |
| Patient resources | |
|---|---|
| Population based register | Yes |
| Clinic based register | Yes |
| Geographically matched controls | No |
Banks
There are no banks for this centre
| Research activities | |
|---|---|
| Clinical management research | Yes |
| Neuro epidemiology | Yes |
| Neuro physiology | Yes |
| Neuro imaging | Yes |
| Neuro psychology | Yes |
| Neuro pathology | No |
| Genomics | Yes |
| Transcriptomics | No |
| Metabolomics | No |
Clinical Trials - Industry sponsored
CARDINALS: A phase 2, randomized, double-blind, placebo- controlled, parallel study to assess the efficacy,safety, tolerability, PK, and biomarker effects of PTC857 in adult subjects with amyotrophic lateral sclerosis.
| Name | Type | Patients |
|---|---|---|
| CARDINALS | Phase 2 | 2 |
Clinical Trials - Investigator initiated
There are no clinical trials for this centre