Medical School Hannover, ALS Centre

The ALS outpatient clinic at Hannover Medical School is the largest ALS centre in Northern Germany. Certified by the German muscular disease society (DGM), we offer multidisciplinary care for ALS patients and patients suffering from other neuromuscular disorders. Close clinical collaborations exist with the departments of pulmonology, gastroenterology, human genetics and palliative care. We have long term experience in national and international multicenter clinical ALS trials. Our clinical research currently focuses on the analysis of co-morbidities, spreading patterns, disease-modifying factors, clinical neurophysiology and imaging. We further pursue research on ALS pathomechanisms and novel therapeutic approaches in human ALS tissue and in cellular and animal models.

Medical School Hannover, ALS Centre
Director

Prof. dr. Martin Stangel, MD
Principal investigator

Prof. dr. Susanne Petri, MD
Contact information
Address

Carl-Neuberg-Str. 1
30625, Hannover
Germany
Contact

Prof. dr. Susanne Petri
Phone

0049 511 532 2392
Fax

0049 511 532 3115
Email petri.susanne@mh-hannover.de
Website Visit the website

Publications

  • Osmanovic A, Rangnau I. Kosfeld A, Abdulla A, Janssen C, Auber B, Raab P, Preller M, Petri S*, Weber R* (2017) (* equal contribution) FIG4 variants in central European patients with amyotrophic lateral sclerosis: a whole-exome and targeted sequencing study. Eur J Hum Genet 25:324-331.
  • Körner S, Böselt S, Wichmann K, Thau-Habermann N, Zapf A, Knippenberg S, Dengler R, Petri S. The Axon Guidance Protein Semaphorin 3A Is Increased in the Motor Cortex of Patients With Amyotrophic Lateral Sclerosis. J Neuropathol Exp Neurol. Feb 25. pii: nlw003.
  • Naujock M, Stanslowsky N, Bufler S, Naumann M, Reinhardt P, Sterneckert J, Kefalakes E, Kassebaum C, Bursch F, Lojewski X, Storch A, Frickenhaus M, Boeckers TM, Putz S, Demstre M, Liebau S, Klingenstein M, Ludolph AC, Dengler R, Kim KS, Hermann A, Wegner F, Petri S (2016) 4-Aminopyridine Induced Activity Rescues Hypoexcitable Motor Neurons from ALS Patient-Derived Induced Pluripotent Stem Cells. Stem Cells, 34:1563-75.
  • Knippenberg S, Rath KJ, Böselt S, Thau-Habermann N, Schwarz S, Dengler R, Wegner F, Petri S (2015). Intraspinal administration of human spinal cord-derived neural progenitor cells in the G93A-SOD1 mouse model of ALS delays symptom progression, prolongs survival and increases expression of endogenous neurotrophic factors. Journal of Tissue Engineering and Regenerative Medicine. DOI: 10.1002/term.1972.
  • Thau N, Knippenberg S, Körner S, Rath KJ, Dengler R, Petri S (2012) Decreased mRNA Expression of PGC-1α and PGC-1α-Regulated Factors in the SOD1G93A ALS Mouse Model and in Human Sporadic ALS. J Neuropathol Exp Neurol 71:1064-74.

Restricted information

Serving population
Serving population

100.000 to 1.000.000
Patient resources
Population based register

No
Clinic based register

Yes
Geographically matched controls

No
Number of muscle samples

30
Number of spinal cord samples

12
Number of brain samples

20
Number of IPS cell samples

10

Banks

There are no banks for this centre

Research activities
Clinical management research

Yes
Neuro epidemiology

No
Neuro physiology

Yes
Neuro imaging

Yes
Neuro psychology

No
Neuro pathology

Yes
Genomics

No
Transcriptomics

No
Metabolomics

No

Clinical Trials - Industry sponsored

Name Type Patients
VITALITY-ALS (Ventilatory Investigation of Tirasemtiv) VITALITY-ALS (Ventilatory Investigation of Tirasemtiv) 10
Levals (Effects of ODM-109 on Respiratory Function) Levals (Effects of ODM-109 on Respiratory Function) 7
BIOGEN Methodology BIOGEN Methodology 8

Clinical Trials - Investigator initiated

Name Type Patients
LIPCAL-ALS (Efficacy, Safety and Tolerability of High Lipid and Calorie Supplementation) LIPCAL-ALS (Efficacy, Safety and Tolerability of High Lipid and Calorie Supplementation) 33
RAS-ALS (Study of Rasagiline) RAS-ALS (Study of Rasagiline) 38