Sheffield Care and Research Centre for Motor Neurone Disorders

The Sheffield Care and Research Centre for Motor Neurone Disorders is based at the Department of Neurology, Royal Hallamshire Hospital which is part of the Sheffield Teaching Hospitals NHS Foundation Trust in the city of Sheffield. The Centre provides multidisciplinary care to patients with Motor Neurone Disease and related disorders appropriate to the needs and wishes of the individual patients and their family members. The Sheffield Centre provides this service to a large regional population based in the North of England and also facilitates the participation of MND/ALS patients in clinical trials and research. Professor Pamela Shaw leads the Centre and is also Director of the Sheffield Institute for Translational Neuroscience (SITraN) based at the University of Sheffield where she leads a major multidisciplinary programme of research investigating genetic, molecular and neurochemical factors underlying neurodegenerative disorders of the human motor system. Dr Christopher McDermott is the Co-Director of the Sheffield Centre and has a research interest in symptom management and therapy management for MND patients. The Centre’s current clinical research interests include; biomarkers of therapeutic response to disease modifying agents in blood and CSF, the value of cough augmentation devices, diaphragm pacing, evidence based optimal timing and technique for gastrostomy tube insertion, secretion management and neck support measures. Principle Investigators in the centre include: Professor Pamela Shaw, Dr Christopher McDermott, Professor Paul Ince. Professor Mimoun Azzouz, Dr Steve Wharton, Dr Robin Highley, Dr Janine Kirby, Dr Tennore Ramesh, Dr Andrew Grierson, Dr Kurt de Vos, Dr Ke Ning, Dr Guillaume Hautbergue. Organisations: University of Sheffield and Sheffield Teaching Hospitals Foundation NHS Trust.

Sheffield Care and Research Centre for Motor Neurone Disorders
Foundation year



Professor Pamela Shaw, Co-Director: Dr. Christopher McDermott

Principal investigator

Professor Pamela Shaw and Dr. Christopher McDermott

Contact information

Sheffield Institute for Translational Neuroscience
385A Glossop Road
S10 2HQ, Sheffield
United Kingdom


+ 44 (0) 114 2222295

Website Visit the website


  • Frequency of the C9ORF72 hexanucleotide repeat expansion in idiopathic amyotrophic lateral sclerosis and fronto-temporal dementia around the world. E Majounie , A E Renton, K Mok , N Nicalou, A Waite, S Rollinson, A Chiò G Restagno, J Simon-Sanchez, J van Swieten , Y Abramzon, JO Johnson, M Sendtner, R Pamphlett, RW Orrell, S Mead , H Houlden, JD Rohrer, K Morrison, K Talbot , O Ansorge , The Chromosome 9-ALS/FTD Consortium, The ITALSGEN Consortium, E Englund , G Borghero, L McCluskey , JQ. Trojanowski, V M. van Deerlin, GD. Schellenberg, MA. Nalls, V Drory, A Brice , C Drepper, N Williams, J Kirby , PJ Shaw, J Hardy, A Singleton, P J Tienari, P Heutink , H Morris , S Pickering-Brown , BJ. Traynor. Lancet Neurology Apr;11(4):323-330;2012.
  • Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72. J Cooper-Knock*, C Hewitt*, J R Highley*, A Brockington, A Milano, S Man, J Martindale, JA Hartley, T Walsh, C Gelsthorpe, L Baxter, G Forster, M Fox, K Mok, CJ McDermott, B Traynor, J Kirby, SB Wharton, PG Ince, J Hardy, PJ Shaw. *Equal contribution. Brain 135:751-764;2012.
  • The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder. BN Smith, S Newhouse, A Shatunov, CVance, Y Lee, S Topp, ME Weale, L Johnson, J Miller, C Troakes, KM Scott, A Jones, I Gray, J Wright, T Hortobágyi S Al-Sarraj, B Rogelj J Powell, M Lupton, S Lovestone, P Sapp, M Weber, PJ Nestor, HJ Schelhaas, A ALM ten Asbroek, V Silani, C Gellera, FTaroni, N Ticozzi, L Van den Berg, J Veldink , P van Damme, W Robberecht, PJ Shaw, J Kirby, H Pall, KE Morrison, A Morris, J de Belleroche, JMB Vianney de Jong, F Baas, PM. Andersen, J Landers, RH Brown, A Al-Chalabi, CE Shaw. Eur J Hum Genet. Jun 13 doi:10.1038ejhg.2012.98; 2012 (Epub ahead of print).
  • The changing landscape of non-invasive ventilation in amyotrophic lateral sclerosis. SC Bourke, CL O’Neill, TL Williams, ET Peel, GJ Gibson, CJ McDermott, PJ Shaw. Invited Editorial J Neurol Neurosurg Psychiatry 83(4):368-369;2012.
  • The chromosome 9 ALS and FTD locus is probably derived from a single founder. K Mok 1, BJ Traynor 2, J Schymick, PJ Tienari3, H Laaksovirta, T Peuralinna, L Myllykangas, A Chiò, A Shatunov, BF. Boeve, AL Boxer, M DeJesus-Hernandez, I R Mackenzie, A Waite, N Williams, HR Morris, J Simón-Sánchez, JC van Swieten, P Heutink, G Restagno, G Mora, KE Morrison, PJ. Shaw PS Rollinson, A Al-Chalabi, R Rademakers, S Pickering-Brown, RW Orrell, M A Nalls, J Hardy. Neurobiol Ageing 33:209 e3-8; 2012.

Restricted information

Serving population
Serving population

100.000 to 1.000.000

Patient resources
Population based register


Clinic based register


Geographically matched controls



There are no banks for this centre

Research activities
Clinical management research


Neuro epidemiology


Neuro physiology


Neuro imaging


Neuro psychology


Neuro pathology








Clinical Trials - Industry sponsored

There are no clinical trials for this centre

Clinical Trials - Investigator initiated

There are no clinical trials for this centre