The LAGENBIO (TERAGEN Y REGENERAGEN) Group, University of Zaragoza

Instituto de Investigación Sanitaria de Aragón-LAGENBIO (TERAGEN Y REGENERAGEN)

The LAGENBIO (TERAGEN Y REGENERAGEN) Group is one of the most experienced research group on ALS in Spain since 1998 and it is a reference center in Aragon. Our group is a multidisciplinary team that will collaborate very closely to the next coming Neuromuscular Clinical Unit in Aragon. One of our main aims deals with the identification and validation of novel prognostic and diagnostic biomarkers of disease to enhance translational studies from the animal model to the ALS patient, and to develop preclinical and clinical assays. In addition, the LAGENBIO Group has also wide expertise of innovative therapeutic approaches at preclinical level.

The LAGENBIO (TERAGEN Y REGENERAGEN) Group, University of Zaragoza
Foundation year	2000
Director	Rosario Osta Pinzolas
Principal investigator	Rosario Osta Pinzolas

Contact information
Address	LAGENBIO. C Miguel Servet, 177 Facultad de Veterinaria, Universidad de Zaragoza 50006 Zaragoza
Contact	Dr. Rosario Osta
Phone	0034761621
Email	osta@unizar.es
Website	Visit the website

Publications

Rando A, Pastor D, Viso-León MC, Martínez A, Manzano R, Navarro X, Osta R, Martínez S. Intramuscular transplantation of bone marrow cells prolongs the lifespan of SOD1(G93A) mice and modulates expression of prognosis biomarkers of the disease. Stem Cell Res Ther. 2018 Apr 6;9(1):90.
Gasco S, Zaragoza P, García-Redondo A, Calvo AC, Osta R. Inflammatory and non-inflammatory monocytes as novel prognostic biomarkers of survival in SOD1G93A mouse model of Amyotrophic Lateral Sclerosis. PLoS One. 2017 Sep 8;12(9):e0184626
Gasco S, Rando A, Zaragoza P, García-Redondo A, Calvo AC, Osta R. Comparative study of hematopoietic stem and progenitor cells between sexes in mice under physiological conditions along time. Cell Biol Int. 2017 Dec;41(12):1399-1405.
Larrodé P, Calvo AC, Moreno-Martínez L, de la Torre M, Moreno-García L, Molina N, Castiella T, Iñiguez C, Pascual LF, Mena FJM, Zaragoza P, Y Cajal SR, Osta R. DREAM-Dependent Activation of Astrocytes in Amyotrophic Lateral Sclerosis. Mol Neurobiol. 2018 Jan;55(1):1-12.
Uffo O, Martínez N, Acosta A, Sanz A, Martín-Burriel I, Osta R, Rodellar C, Zaragoza P. Analysis of microsatellite markers in a Cuban water buffalo breed. J Dairy Res. 2017 Aug;84(3):289-292.

Restricted information

Serving population
Serving population	1.3 million

Patient resources
Population based register	No
Clinic based register	No
Geographically matched controls	No

Banks

There are no banks for this centre

Research activities
Clinical management research	No
Neuro epidemiology	No
Neuro physiology	No
Neuro imaging	No
Neuro psychology	No
Neuro pathology	No
Genomics	No
Transcriptomics	Yes
Metabolomics	Yes

Clinical Trials - Industry sponsored

There are no clinical trials for this centre

Clinical Trials - Investigator initiated